CCR4 antibody

• Catalog Number: orb613910
• Category: Antibodies
• Description: Rabbit monoclonal antibody to CCR4
• Species/Host: Human
• Clonality: Monoclonal
• Clone Number: KW-0761 (Mogamulizumab)
• Tested applications: Depletion
• Reactivity: Human
• Isotype: IgG
• Immunogen: This antibody was prepared by humanization of a mouse anti-CCR4 mAb.
• Concentration: 1 mg/ml
• Purity: Purified
• Conjugation: Unconjugated
• Target: CCR4
• UniProt ID: P51679
• Storage: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
• Buffer/Preservatives: PBS with 0.02% Proclin 300.
• Alternative names: CD194; CKR-4; CCR-4; CCR4; K5-5
• Note: For research use only
• Application notes: The clinically used format of this antibody (which underwent additional de-fucosylation to increase antibody-dependent cellular cytotoxicity (ADCC)), has significant clinical activity in heavily pretreated patients with mycosis fungoides and Sézary syndrome, and is associated with an overall response rate of 36.8% and a median duration of response of 10.4 months (Duvic et al, 2014). It was shown to CCR4-expressing cells by antibody-dependent, cell-mediated cytotoxicity (ADCC). Therapeutically, this results in a dual mechanism of action; in addition to directly targeting malignant T cells over-expressing CCR4, this antibody also depletes T reg cells, an important therapeutic target in human cancers. This antibody is well-tolerated, and administration does not appear to trigger clinically significant autoimmune complications in phase 1/2 trials (Duvic et al, 2014). This antibody has been approved in Japan for the treatment of relapsed or refractory adult T-cell leukemia/lymphoma, and is in clinical trials for solid cancers. For the avoidance of doubt - the material produced by Biorbyt has not been de-fucosylated.
• Expiration Date: 12 months from date of receipt.