CCND3 antibody

• Catalog Number: orb107017
• Category: Antibodies
• Description: Rabbit polyclonal to CCND3. Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
• Species/Host: Rabbit
• Clonality: Polyclonal
• Clone Number: RB43029
• Tested applications: IHC-P, WB
• Reactivity: Human, Mouse
• Isotype: Rabbit IgG
• Immunogen: Synthetic Peptide
• Dilution range: WB: 1:1000
• Form/Appearance: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Conjugation: Unconjugated
• MW: 32520
• Target: CCND3
• UniProt ID: P30281
• NCBI: NP_001129489.1, NP_001751.1, NP_001129598.1, NP_001129597.1
• Alternative names: anti CCND3 antibody, anti G1/S-specific cyclin-D3
• Note: For research use only
• Expiration Date: 12 months from date of receipt.

Western blot analysis of MDA-MB231 cell line lysates (35ug/lane) using CCND3 antibody (C-term S274)