BING

• Catalog Number: orb1140498
• Category: Proteins
• Description: Antimicrobial peptide isolated from Japanese medaka fish; Antibacterial; Antimicrobial peptides.
• Modifications: None
• Structure: H-Ile-Arg-Ile-Ile-Leu-Arg-Ala-Gln-Gly-Ala-Leu-Lys-Ile-OH
• Target Areas: Antibacterials
• Form/Appearance: Freeze dried solid
• Purity: > 95% by hplc
• MW: 1464.86 Da
• Formula: C₆₇H₁₂₅N₂₁O₁₅
• Solubility (25°C): Soluble in water
• Protein Sequence: H-Ile-Arg-Ile-Ile-Leu-Arg-Ala-Gln-Gly-Ala-Leu-Lys-Ile-OH
• Storage: Store dry, frozen and in the dark
• Alternative names: AM280, BING, Blocker of INter-membrane stress resp
• Background: BING is an antimicrobial peptide found in the plasma of the Japanese rice fish medaka (Oryzias latipes), derived from vacuolar protein sorting-associated protein 13D-like (Vps13D). BING possesses toxicity against a broad range of gram-positive and negative bacteria including drug resistant strains, at concentrations that have low toxicity to mammalian cell lines. BING treatment induces deregulation of periplasmic peptidyl-prolyl isomerases in gram-negative bacteria and also reduces the RNA level of cpxR, an upstream regulator of envelope stress responses which plays a crucial role in the development of antimicrobial resistance.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.