BI-2865

• Catalog Number: orb1818845
• Category: Small Molecules
• Description: BI-2865 is a none-covalent pan-KRAS Inhibitor. BI-2865 blocked nucleotide exchange to prevent the activation of wild-type KRAS and a broad range of KRAS mutants, including G12A/C/D/F/V/S, G13C/D, V14I, L19F, Q22K, D33E, Q61H, K117N and A146V/T. Inhibition of downstream signalling and proliferation was restricted to cancer cells harbouring mutant KRAS, and drug treatment suppressed KRAS mutant tumour growth in mice, without having a detrimental effect on animal weight.
• CAS Number: [2937327-93-8]
• MW: 465.571182489395
• SMILES: C12CCC[C@](C)(C3ON=C(C4=NC=CC(O[C@H]([C@@H]5CCCN5C)C)=N4)N=3)C=1C(C#N)=C(N)S2
• Formula: C₂₃H₂₇N₇O₂S
• Note: For research use only
• Expiration Date: 12 months from date of receipt.