BI-2865

• Catalog Number: orb1737458
• Category: Small Molecules
• Description: BI-2865
• CAS Number: 2937327-93-8
• Purity: 0.98
• MW: 465.57
• SMILES: C[C@]1(C2=C(SC(N)=C2C#N)CCC1)C3=NC(=NO3)C=4N=C(O[C@@H](C)[C@@]5(CCCN5C)[H])C=CN4
• Formula: C₂₃H₂₇N₇O₂S
• Biological Activity: BI-2865 is a non-covalent pan-KRAS inhibitor.BI-2865 binds to KRAS WT, G12C, G12D, G12V, and G13D mutants with KD values of 6.9, 4.5, 32, 26, and 4.3 nM, respectively.BI-2865 showed antiproliferative activity in BaF3 cells expressing KRAS G12C, G12D, or G12V mutants. BI-2865 showed antiproliferative activity on BaF3 cells expressing KRAS G12C, G12D or G12V mutants with an average IC50 value of approximately 140 nM.
• Storage: -20°C
• Note: For research use only
• Expiration Date: 12 months from date of receipt.