BCR antibody

• Catalog Number: orb153748
• Category: Antibodies
• Description: Rabbit polyclonal antibody to BCR. The breakpoint cluster region protein (Bcr) is best know to be involved in genomic translocation with fusion partner Abl (Cbr-Abl) causing chronic myelogenous leukemia (CML). This 160 kDa protein contains a serine/threonine kinase domain, an SH2 binding domain, a GTP/GDP exchange domain and a C-term domain which functions as a GTPase activating protein for p21rac and CDC42. Additionally, Bcr is involved in signal transduction and can down regulate Ras mediated cell signaling.
• Clonality: Polyclonal
• Tested applications: IHC, WB
• Reactivity: Human, Mouse, Rat
• Isotype: IgG
• Immunogen: Recombinant fusion protein of human BCR(NP_004318.3).
• Dilution range: WB: 1:500-2000, IHC-P: 1:50-100
• Conjugation: Unconjugated
• MW: 150kDa
• UniProt ID: P11274
• Storage: Store at -20°C. Avoid freeze / thaw cycles.
• Buffer/Preservatives: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
• Alternative names: anti ALL antibody, anti BCR1 antibody, anti CML an
• Note: For research use only
• Expiration Date: 12 months from date of receipt.

Western blot analysis of extracts of various cells using BCR antibody

Immunohistochemical staining of human stomach tissue using BCR antibody (dilution of 1:100)

Immunohistochemical staining of human prostate tissue using BCR antibody (dilution of 1:100)