ATP citrate lyase/ACLY Protein, Human, Recombinant (His)

• Catalog Number: orb1957197
• Category: Proteins
• Description: ATP citrate lyase, also known as Acly or Acl, is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is composed of two polymer chains which are polypeptides in human. ATP citrate lyase is responsible for catalyzing the conversion of citrate and CoA into acetyl-CoA and oxaloacetate, along with the hydrolysis of ATP. A definitive role for ATP citrate lyase in tumorigenesis has emerged from ATP citrate lyase RNAi and chemical inhibitor studies, showing that ATP citrate lyase inhibition limits tumor cell proliferation and survival and induces differentiation in vitro. In vivo, it reduces tumor growth leading to a cytostatic effect and induces differentiation.
• Tag: N-His
• Purity: 96.00%
• UniProt ID: P53396
• MW: 123 kDa (predicted); 110 kDa (reducing conditions)
• Application notes: A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
• Expression System: Baculovirus Insect Cells
• Biological Origin: Human
• Expression Region: A DNA sequence encoding the human ACLY (P53396) (Met 1-Met 1101) was expressed, with a polyhistidine tag at the N-terminus. Predicted N terminal: Met
• Storage: -20°C
• Note: For research use only
• Expiration Date: 6 months from date of receipt.