ATI 2341

• Catalog Number: orb1140485
• Category: Proteins
• Description: CXCR4 allosteric agonist; Peptides.
• CAS Number: 1337878-62-2
• Form/Appearance: Freeze dried solid
• Purity: > 95% by hplc
• MW: 2256.82 Da
• Formula: C₁₀₄H₁₇₈N₂₆O₂₅S₂
• Structure: Pal-Met-Gly-Tyr-Gln-Lys-Lys-Leu-Arg-Ser-Met-Thr-Asp-Lys-Tyr-Arg-Leu-OH
• Solubility (25°C): Soluble to 1 mg/ml in water
• Protein Sequence: Pal-MGYQKKLRSMTDKYRL
• Storage: Store dry, frozen and in the dark
• Alternative names: , 1337878-62-2, ATI 2341, MGYQKKLRSMTDKYRL, Pal-MG
• Background: ATI 2341 is a pepducin targeting the C-X-C chemokine receptor type 4 (CXCR) at which it is an allosteric agonist with an EC50 of 194 nM. ATI 2341 functions as a biased ligand, favouring Gαi activation over Gα13. In contrast to the the natural CXCR4 agonist, stromal cell-derived factor-1α, ATI 2341 does not promote β-arrestin recruitment. ATI 2341 induces chemotaxis in CXCR4 expressing cells in vitro and acts as a functional antagonist to mobilise polymorphonuclear neutrophils and hematopoietic stem and progenitor cells from bone marrow niche in both mice and non-human primates.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.