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Catalog Number | orb546977 |
---|---|
Category | Antibodies |
Description | APC Monoclonal Antibody |
Species/Host | Rabbit |
Clonality | Monoclonal |
Clone Number | FAD-1 |
Tested applications | ICC, IF, IHC, IP, WB |
Reactivity | Human, Mouse, Rat |
Isotype | Rabbit IgG |
Immunogen | A synthesized peptide derived from human APC Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF) -induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. |
Concentration | Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure. |
Dilution range | WB 1:500-1:2000IHC 1:50-1:200ICC/IF 1:50-1:200IP 1:50 |
Form/Appearance | Liquid |
Conjugation | Unconjugated |
UniProt ID | P25054 |
Storage | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |
WB analysis of APC using anti-APC antibody in 293T Cell.
IHC analysis of APC using anti-APC antibody in human colon cancer samples.APC was detected in paraffin-embedded section.
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