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Amyloid Oligomers (A11) Antibody: APC
Catalog Number: orb152852
| Catalog Number | orb152852 |
|---|---|
| Category | Antibodies |
| Description | Rabbit polyclonal to Amyloid Oligomers (APC). Amyloid monomeric proteins can sometimes oligomerize into destructive amyloid fibrils. Amyloidogenic conformations of non-disease related proteins can be created by partial protein misfolding or denaturation. Many degenerative diseases are known to be related to the accumulation of misfolded proteins as amyloid fibres. These include the amyloid- beta peptide plaques and tau neurofibrillary tangles in senile plaques of Alzheimers symptomology, the deposition of alpha-synuclein in the Lewy bodies of Parkinsons disease, and accumulation of polyglutamine-containing aggregates in Huntingtons disease. |
| Target | Amyloid Oligomers (A11) |
| Clonality | Polyclonal |
| Species/Host | Rabbit |
| Conjugation | APC |
| Reactivity | Human, Mouse, Other, Rat |
| Buffer/Preservatives | 95.64mM Phosphate, 2.48mM MES and 2mM EDTA |
| Purification | Protein A Purified |
| Immunogen | Synthetic molecular mimic of soluble oligomers |
| UniProt ID | P05067 |
| Tested applications | ICC, IF, IHC |
| Dilution range | The suggested dilution for the current lot of SPC-506 in Western Blot and Dot Blot is 1:100 |
| Application notes | A 1:200 dilution of SPC-506 was sufficient for detection of amyloid oligomers in 10 µg of mouse brain lysates by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody. |
| Storage | Conjugated antibodies should be stored according to the product label |
| Alternative names | Amyloid Oligomer alpha beta antibody, A11 antibody Read more... |
| Note | For research use only |
| Entrez | 8666 |
| NCBI | NM_000484.2 |
Immunohistochemistry analysis using Rabbit Anti-Amyloid Oligomers (A11) Polyclonal Antibody. Tissue: Alzheimer's Disease brain. Species: Human. Fixation: Formalin fixed. Primary Antibody: Rabbit Anti-Amyloid Oligomers (A11) Polyclonal Antibody at 1:1000. Secondary Antibody: Goat Anti-Rabbit ATTO 594 (red). Localization: Plaque. (A) Amyloid Fibril (OC) Antibody. (B) Amyloid Oligomer (A11) Antibody. (C) Composite.
Western blot analysis of Human Abeta42 fibrils and prefibrillar oligomers showing detection of Amyloid Oligomers (A11) protein using Rabbit Anti-Amyloid Oligomers (A11) Polyclonal Antibody. Primary Antibody: Rabbit Anti-Amyloid Oligomers (A11) Polyclonal Antibody at 1:1000.
Dot blot analysis using Rabbit Anti-Amyloid Oligomers (A11) Polyclonal Antibody. Tissue: Abeta42 fibrils and prefibrillar oligomers. Species: Human. Primary Antibody: Rabbit Anti-Amyloid Oligomers (A11) Polyclonal Antibody at 1:1000.
