AMPR-22

• Catalog Number: orb1140467
• Category: Proteins
• Description: Antimicrobial peptide derived from Romo1; Antibacterial; Antimicrobial peptides
• Modifications: None
• Structure: H-Lys-Lys-Met-Met-Lys-Lys-Gly-Gly-Lys-Phe-Gly-Thr-Phe-Met-Ala-Ile-Gly-Gly-Ile-Arg-OH
• Target Areas: Antibacterials
• Form/Appearance: Freeze dried solid
• Purity: > 95% by hplc
• MW: 2186.78 Da
• Formula: C₉₈H₁₆₈N₂₈O₂₂S₃
• Solubility (25°C): Soluble in water
• Protein Sequence: H-Lys-Lys-Met-Met-Lys-Lys-Gly-Gly-Lys-Phe-Gly-Thr-Phe-Met-Ala-Ile-Gly-Gly-Ile-Arg-OH
• Storage: Store dry, frozen and in the dark
• Alternative names: AMPR-22KKMMKKGGKFGTFMAIGGIR, antimicrobial peptide
• Background: AMPR-22 is an optimised antimicrobial peptide derived from reactive oxygen species modulator 1 (Romo1), a mitochondrial protein encoded by the nucleus which is a nonselective cation channel in the mitochondrial inner membrane. AMPR-22 shows broad-spectrum antimicrobial activity against 17 sepsis causing bacteria, including multidrug resistant (MDR) strains, by inducing membrane permeabilization. In vivo, AMPR-22 enables a remarkable survival rate in mice injected with MDR bacteria in murine models of sepsis.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.

Structure of AMPR-22