AGO2 (N2) Antibody, Rabbit Polyclonal

SKU: orb67055

Description

Rabbit polyclonal to AGO2.Protein argonaute-2 (AGO2) is also known as Eukaryotic translation initiation factor 2C 2 (EIF2C2),which is required for RNA-mediated gene silencing NAi) by the RNA-induced silencing complexISC). The 'minimal RISC' appears to include EIF2C2/AGO2 bound to a short guide RNA such as amicroRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC tocomplementary mRNAs that are targets for RISC-mediated gene silencing. Binding of RISC to aperfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of themRNA specifically by EIF2C2/AGO2. The inhibition of translational initiation leads to the accumulationof the affected mRNA in cytoplasmic processing bodies (P-bodies), where mRNA degradation maysubsequently occur.

Research Area

Epigenetics

Images & Validation

• Tested Applications: WB
• Dilution Range: WB:1:1000-1:5000
• Reactivity: Human, Mouse

Key Properties

• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: N-terminal region of human AGO2
• Molecular Weight: 97
• Purity: Affinity purification
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Buffer/Preservatives: 0.01% NaN3
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

anti-AGO2 antibody,anti-EIF2C2 antibody,anti-Protein argonaute2 antibody,anti-Argonaute2 antibody,anti-hAgo2 antibody,anti-Eukaryotic translation initiation factor 2C 2 antibody,anti-eIF2C 2 antibody,anti-eIF2C 2 antibody,anti-PAZ Piwi domain protein antibody,anti-PPD antibody,anti-Protein slicer antibody

Quick Database Links

UniProt

Q9UKV8