AAPK-25

• Catalog Number: orb1310030
• Category: Small Molecules
• Description: AAPK-25
• CAS Number: 2247919-28-2
• Purity: 97.79%
• MW: 442.32
• SMILES: Clc1ccc(cc1Cl)C(=O)Nc1ccc2cc(ccc2c1)C(=O)Nc1nccs1
• Formula: C₂₁H₁₃Cl₂N₃O₂S
• Biological Activity: AAPK-25, a potent and selective dual inhibitor of Aurora/PLK, causes mitotic delay and cell arrest in prometaphase, via phosphorylation of the biomarker histone H3Ser10, followed by a surge in apoptosis. AAPK-25 targets Aurora A, Aurora B, and Aurora C with Kd values ranging from 23-289 nM, and PLK1, PLK2, and PLK3 with Kd values ranging from 55-456 nM. AAPK-25 has antitumor activity.
• Storage: -20°C
• Note: For research use only
• Expiration Date: 12 months from date of receipt.