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Catalog Number | orb1140473 |
---|---|
Category | Proteins |
Description | ANXA1-EphA2 interaction blocker; Cell penetrating peptides. |
Form/Appearance | Freeze dried solid |
Purity | > 95% by hplc |
MW | 2767.19 Da |
Formula | C117H204N46O32 |
H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Glu-Tyr-Val-Gln-Thr-Val-Lys-Ser-Ser-Lys-Gly-OH | |
Solubility (25°C) | Soluble in water |
Protein Sequence | YGRKKRRQRRREYVQTVKSSKG |
Storage | Store dry, frozen and in the dark |
Alternative names | A11, ANXA1-derived 11 amino acid-long peptidePP250 Read more... |
Background | A11 is a peptide derived from amino acid residues 20-30 of the ANXA1 N-terminus fused to the cell penetrating peptide CPP. A11blocks ANXA1 competition with the E3 ubiquitin ligase Cbl for binding EphA2, enhancing Cbl-mediated EphA2 ubiquitination and degradation, and reducing the oncogenicmechanism of the ANXA1- EphA2 interaction in nasopharyngeal carcinoma (NPC). A11 can suppress NPC cell growth in vitro and in vivo. |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |
> 96% as determined by SDS-PAGE and HPLC. | |
8.4 kDa | |
E.Coli |
> 96% as determined by SDS-PAGE and HPLC. | |
8.4 kDa | |
E.Coli |
> 97% as determined by SDS-PAGE and HPLC. | |
8.4 kDa | |
E.Coli |
FC, WB | |
Human, Mouse | |
Monoclonal | |
Unconjugated |
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