A11

• Catalog Number: orb1140473
• Category: Proteins
• Description: ANXA1-EphA2 interaction blocker; Cell penetrating peptides.
• Modifications: None
• Structure: H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Glu-Tyr-Val-Gln-Thr-Val-Lys-Ser-Ser-Lys-Gly-OH
• Target Areas: Protein-protein interactions
• Form/Appearance: Freeze dried solid
• Purity: > 95% by hplc
• MW: 2767.19 Da
• Formula: C₁₁₇H₂₀₄N₄₆O₃₂
• Solubility (25°C): Soluble in water
• Protein Sequence: H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Glu-Tyr-Val-Gln-Thr-Val-Lys-Ser-Ser-Lys-Gly-OH
• Storage: Store dry, frozen and in the dark
• Alternative names: A11, ANXA1-derived 11 amino acid-long peptidePP250
• Background: A11 is a peptide derived from amino acid residues 20-30 of the ANXA1 N-terminus fused to the cell penetrating peptide CPP. A11blocks ANXA1 competition with the E3 ubiquitin ligase Cbl for binding EphA2, enhancing Cbl-mediated EphA2 ubiquitination and degradation, and reducing the oncogenicmechanism of the ANXA1- EphA2 interaction in nasopharyngeal carcinoma (NPC). A11 can suppress NPC cell growth in vitro and in vivo.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.