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    5A2-SC8

    5A2-SC8

    Catalog Number: orb1473197

    DispatchUsually dispatched within 5-10 working days
    $ 2,085.00
    Catalog Numberorb1473197
    CategorySmall Molecules
    Description5A2-SC8 is a degradable lipid-like compound (ester-based dendrimer) for small RNAs delivery.5A2-SC8, was obtained by screening a large library of more than 1500 ester-based dendrimers containing ionizable amino groups, which have three tertiary amine heads and five lipid tails. Based on this library, the in vitro transfection efficiency of different formulations of 5A2-SC8 iLNPs was evaluated, discovering the optimal formulation (5A2-SC8, DOPE, cholesterol, PEG at a molar ratio of 15:15:30:3) of 5A2-SC8 iLNPs for delivering fumarylacetoacetate hydrolase (FAH) mRNA to liver.After the intravenous injection via tail, the model mice of hepatorenal tyrosinemia type I had strong FAH protein expression, which prevented body weight loss and increased the survival rate of hepatorenal tyrosinemia mice . In addition to introducing utility of 5A2-SC8 iLNPs for the therapeutic intervention, the 5A2-SC8 iLNPs containing DOTAP have been used to establish complex mouse models via intravenous injection, including in situ liverspecific cancer model and in situ lung-specific cancer model. Based on this iLNPs delivery system, 5A2-SC8 induced model construction method overcomes the time-consuming and costly disadvantages of traditional animal models establishing methods, including transgenesis and gene engineering in embryonic stem cells.
    CAS Number[1857341-90-2]
    MW1841.72
    SMILESC(OCCOC(=O)C(C)CSCCCCCCCC)(=O)CCN(CCC(OCCOC(=O)C(C)CSCCCCCCCC)=O)CCNCCN(CCC(OCCOC(=O)C(C)CSCCCCCCCC)=O)CCNCCN(CCC(OCCOC(=O)C(C)CSCCCCCCCC)=O)CCC(OCCOC(=O)C(C)CSCCCCCCCC)=O
    FormulaC93H173N5O20S5
    NoteFor research use only
    Expiration Date12 months from date of receipt.
    • 5A2-SC8 [orb1982929]

      98.00%

      1857341-90-2

      1841.72

      C93H173N5O20S5

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