Zonisamide

SKU: orb1310776

Description

Zonisamide (AD 810) is a sulfonamide anticonvulsant used adjunctively for partial-onset seizures. Its primary mechanisms involve blocking voltage-gated sodium channels and T-type calcium currents, with additional allosteric modulation of GABA receptors. This research chemical is applied in neuroscience studies, including in vitro electrophysiology and in vivo seizure models, to investigate antiepileptic pathways.

Research Area

Cell Biology, Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 68291-97-4
• MW: 212.226
• Purity: >99.99% (May vary between batches)
• Formula: C₈H₈N₂O₃S
• SMILES: O=S(CC1=NOC2=C1C=CC=C2)(N)=O
• Target: Calcium Channel,Sodium Channel,Carbonic Anhydrase,Apoptosis
• Solubility: DMSO:250 mg/mL (1177.97 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (9.42 mM)

Bioactivity

• Target IC50:
  CA V (human):20.6 nM (Ki)|CA II (human):35.2 nM (Ki)
• In Vivo:
  Zonisamide inhibits monoamine oxidase B activity in vitro with an IC50 of 25 μM.
• In Vitro:
  Zonisamide inhibits monoamine oxidase B activity in vitro with an IC50 of 25 μM.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Sodium Channel, SodiumChannel, SH-SY5Y, seizure, Zonisamide, CI 912, CI912, CI-912, AD810, AD-810, AD 810, Apoptosis, Calcium Channel, cardiac fibroblasts, cardiac hypertrophy, CarbonicAnhydrase, Carbonic Anhydrase, Carbonic anhydrase, Carbonate dehydratase, CalciumChannel, inhibit, NRCMs, parkinson's disease, Inhibitor, epilepsy

Compound Identifiers

PubChem CID

5734