WHI-P97

SKU: orb1302679

Description

WHI-P97 is a potent, rationally designed JAK3 inhibitor (IC50 provided). It suppresses IgE-mediated leukotriene synthesis in mast cells by blocking 5-lipoxygenase nuclear translocation without direct enzyme inhibition. This mechanism supports its research use in studying allergic inflammation and mast cell biology in vitro.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 211555-05-4
• MW: 455.1
• Purity: 99.93%
• Formula: C₁₆H₁₃Br₂N₃O₃
• SMILES: COc1cc2ncnc(Nc3cc(Br)c(O)c(Br)c3)c2cc1OC
• Target: JAK
• Solubility: DMSO:60 mg/mL (131.84 mM);10% DMSO+40% PEG300+5% Tween-80+45% Saline:1 mg/mL (2.2 mM)

Bioactivity

• Target IC50:
  JAK3:11 μM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

airway, inhibit, JAK, JAK3, Janus kinase, ovalbumin-sensitized, ovalbumin challenge, Inhibitor, eosinophil recruitment, WHI-P97, WHI-P-97, WHIP97, WHI P97

Compound Identifiers

PubChem CID

3796