VX-680 (MK-0457,Tozasertib)

• Catalog Number: orb154659
• Category: Small Molecules
• Description: VX-680 (MK-0457, Tozasertib) is a pan-Aurora inhibitor of Aurora A, Aurora B and Aurora C with Kiapp of 0.6 nM, 18 nM and 4.6 nM, respectively.
• CAS Number: [639089-54-6]
• MW: 464.59
• SMILES: CC1=CC(=NN1)NC2=NC(=NC(=C2)N3CCN(CC3)C)SC4=CC=C(C=C4)NC(=O)C5CC5
• Formula: C₂₃H₂₈N₈OS
• Note: For research use only
• Expiration Date: 12 months from date of receipt.

VX-680 chemical structure

VX-680