VV116

• Catalog Number: orb1473047
• Category: Small Molecules
• Description: VV116, also known as JT001, is an oral drug candidate of nucleoside analog against SARS-CoV-2. VV116 is a deuterated, tri-isobutyrate ester prodrug of the RDV parent nucleoside, and is rapidly metabolized into the parent nucleoside (116-N1) in the body. 116-N1 is intracellularly converted to the nucleoside triphosphate active form, which would interfere with the function of RNA-dependent RNA polymerase of SARS-CoV-2, thus exerting antiviral effects (Fig. 1). VV116 showed potent activity against a panel of SARS-CoV-2 variants (alpha, beta, delta, and omicron) and excellent therapeutic efficacy in the mice model.
• CAS Number: [2647442-33-7]
• Purity: > 98%
• MW: 502.22
• SMILES: CC(C(OC[C@H]1O[C@](C#N)([C@@H]([C@@H]1OC(C(C)C)=O)OC(C(C)C)=O)C2=CC([2H])=C3N2N=CN=C3N)=O)C
• Formula: C₂₄H₃₀DN₅O₇
• Storage: Store at -20°C
• Alternative names: VV-116, VV 116
• Note: For research use only
• Expiration Date: 12 months from date of receipt.

Chemical Structure of VV116