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Catalog Number | orb150491 |
---|---|
Category | Antibodies |
Description | Mouse monoclonal to Versican (FITC). Versican (chondroitin sulfate proteoglycan 2) is a large extracellular matrix proteoglycan involved in cell growth and differentiation. Important as a structural molecule, versican creates loose and hydrated matrices during key events in development and disease. The protein contains hyaluronic acid and glycosminoglycan-binding domains, epidermal growth factor-like repeats, a Lectinlike sequence and a complement regulatory protein-like domain. Splice variants differ greatly in length and degree of modification by glycoaminoglycan chains. Accumulation around smooth muscle cells in lesions of athero-sclerosis suggests a role for versican in atherogenesis. Versican, differentially expressed in human melanoma, plays a role in tumor development and may be a reliable marker for clinical diagnosis. The organization of HA- and versican-rich pericellular matrices may faciliatate migration and mitosis by diminishing cell surface adhesivity and affecting cell shape through steric exclusion and the viscous properties of HA proteoglycan gels.. |
Species/Host | Mouse |
Clonality | Monoclonal |
Clone Number | S351-23 |
Tested applications | ICC, WB |
Reactivity | Human, Mouse, Rat |
Isotype | IgG1 |
Immunogen | Fusion protein amino acids 362-585 (glycosaminoglycan alpha domain) of mouse Versican core protein |
Concentration | 1 mg/ml |
Dilution range | WB (1:1000), ICC/IF (1:100) |
Conjugation | FITC |
MW | 350kDa |
Target | Versican |
Entrez | 13003 |
UniProt ID | Q62059 |
NCBI | AAH96495 |
Storage | Conjugated antibodies should be stored at 4°C |
Buffer/Preservatives | PBS pH 7.4, 50% glycerol, 0.1% sodium azide *Storage buffer may change when conjugated |
Alternative names | Chondroitin sulfate proteoglycan 2 antibody, CSPG2 Read more... |
Note | For research use only |
Application notes | 1 µg/ml of SMC-439 was sufficient for detection of Versican in 20 µg of mouse brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody. |
Expiration Date | 12 months from date of receipt. |
IHC, WB | |
Human, Mouse, Rat | |
Rabbit | |
Polyclonal | |
Unconjugated |
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