Vecuronium bromide

SKU: orb1224894

Description

Vecuronium (bromide) is a muscle relaxant in the category of non-depolarizing blocking agents.(In Vitro):Vecuronium bromide (0-100 μM, 15 min) inhibits [3H] norepinephrine (NE) uptake to 65% at 100 μM in adrenal medullary cells.Vecuronium bromide (0-15 μM,72 hours) inhibits cancer cell proliferation and migration in a concentration-dependent manner.Vecuronium bromide (0-15 μM,72 hours) can significantly reduce cell viability by combining with cisplatin.(In Vivo):Vecuronium bromide (Intravenous injection, 0-5 μM, every 30 min, 2 hours) attenuates the response of carotid sinus nerve activity (CSNA) to hypoxia in a dose-dependent manner and inhibits the neural response of the carotid body to acetylcholine (ACh) in Wister rats.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 50700-72-6
• MW: 637.73
• Purity: >98% (HPLC)
• Formula: C₃₄H₅₇BrN₂O₄
• SMILES: CC(O[C@@H]1[C@@H](N2CCCCC2)C[C@]3(C)[C@@]4([H])CC[C@]5(C)[C@H](OC(C)=O)[C@@H]([N+]6(C)CCCCC6)C[C@@]5([H])[C@]4([H])CC[C@@]3([H])C1)=O.[Br-]
• Target: AChR
• Solubility: Ethanol: 100 mg/mL (156.8 mM); Water: 4 mg/mL (6.27 mM); DMSO: 100 mg/mL (156.8 mM)

Bioactivity

• In Vivo:
  Vecuronium bromide (Intravenous injection, 0-5 μM, every 30 min, 2 hours) attenuates the response of carotid sinus nerve activity (CSNA) to hypoxia in a dose-dependent manner and inhibits the neural response of the carotid body to acetylcholine (ACh) in Wister rats. Animal model: Wister rats weighing 250-350 g. Dosage: 0-5 μM. Administration: Intravenous injection; every 30 min; 2 hours. Result: Significantly diminished CSNA response to hypoxia at the concentration of 5 μM and reduced carotid sinus nerve response to ACh at 0.5 μM.
• In Vitro:
  Vecuronium bromide (0-100 μM, 15 min) inhibits [3H] norepinephrine (NE) uptake to 65% at 100 μM in adrenal medullary cells. Vecuronium bromide (0-15 μM, 72 hours) inhibits cancer cell proliferation and migration in a concentration-dependent manner. Vecuronium bromide (0-15 μM, 72 hours) can significantly reduce cell viability by combining with cisplatin. Cell Proliferation Assay Cell line: Lung cancer cell line (A549). Concentration: 0-15 μM. Incubation time: 72 hours. Result: Inhibited cell proliferation at concentrations ranging from 5.0 μM to 15 μM. Cell Cytotoxicity Assay Cell line: Lung cancer cell line (A549). Concentration: 0-15 μM. Incubation time: 72 hours. Result: Resulted in a decrease in cell viability from 10 μM to 15 Μm by combining with cisplatin.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NC 45

Quick Database Links

Gene Symbol

AChR