Valpha TCR antibody

• Catalog Number: orb348924
• Category: Antibodies
• Description: Rabbit monoclonal antibody to Valpha TCR
• Species/Host: Mouse
• Clonality: Monoclonal
• Clone Number: 34
• Tested applications: ELISA, FC, WB
• Reactivity: Human
• Isotype: IgG
• Immunogen: Purified recombinant soluble TCR from the T-cell hybridoma 85.33, corresponding to V alpha 11
• Concentration: 1 mg/ml
• Purity: Purified
• Conjugation: Unconjugated
• Target: Vα TCR
• UniProt ID: P01848
• Storage: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
• Buffer/Preservatives: PBS with 0.02% Proclin 300.
• Alternative names: TCR variable alpha chain; T-cell receptor variable
• Note: For research use only
• Application notes: The antibody binds specifically to the recombinant and native variable domain of the α chain which comprises the T-cell receptor (TCR). The TCR is a disulfide-linked heterodimeric protein expressed on the surface of T-cells in complex with CD3 and ζ-chain molecules. The receptor functions in the recognition of MHC molecule and the subsequent activation of T-cells. The monoclonal antibody 34 recognises Vα regions of TCRs expressed in the 85.33 arthritogenic T-cell hybridoma and can be used to analyse TCR V gene expression and for immunotherapy in T cell mediated autoimmunity.
• Expiration Date: 12 months from date of receipt.

References

Popov, S. et al. A novel and efficient route for the isolation of antibodies that recognise T cell receptor V alpha(s) Mol Immunol, 33, 493-502 (1996)

PubMed: 8700165