UNC 926 hydrochloride

SKU: orb1223403

Description

UNC-926 inhibits L3MBTL1 (IC50: 3.9 μM). UNC-926 also exhibits a low micromolar affinity for L3MBTL3. UNC-926 inhibits binding of the 3xMBT domain to H4K20me1. It selectively and dose-dependently inhibits the L3MBTL13xMBT-H4K20me1 interaction. UNC-926 has not an effect on the binding of 53BP1 to H4K20me1.

Key Properties

• CAS Number: 1184136-10-4
• MW: 373.72
• Purity: >98% (HPLC)
• Formula: C₁₆H₂₁BrN₂O·HCl
• SMILES: C1CCN(C1)C1CCN(CC1)C(=O)c1cc(ccc1)Br
• Target: L3MBTL1
• Solubility: In Vitro: DMSO : 41.67 mg/mL (123.56 mM)

Bioactivity

• In Vitro:
  UNC926 also exhibits a low micromolar affinity for the close homolog, L3MBTL3 ( IC50 of 3.2 μM), with a decrease in affinity for the other MBT domains and no binding to CBX7.UNC926 (1-25 μM) inhibits binding of the 3xMBT domain to H4K20me1.UNC926 inhibits the association of L3MBTL13xMBT with the appropriate histonepeptides in a dose-dependent manner. UNC926 does not have an effect on the binding of 53BP1 to H4K20me1, demonstrating specificity of UNC926 for L3MBTL1 over 53BP1.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

L3MBTL1