TSC1 antibody

• Catalog Number: orb67145
• Category: Antibodies
• Description: Rabbit polyclonal to TSC1.Tuberous sclerosis 1 protein (TSC1) is a peripheral membrane protein. In complex with TSC2, TSC1inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 bynegatively regulating mTORC1 signaling. It seems not to be required for TSC2 GAP activity towardsRHEB. It is implicated as a tumor suppressor. TSC1 is involved in microtubule-mediated proteintransport, but this seems to be due to unregulated mTOR signaling. Defects in TSC1 are the cause oftuberous sclerosis type 1 (TSC1) and may be the cause of focal cortical dysplasia of Taylor ballooncell type (FCDBC).
• Species/Host: Rabbit
• Clonality: Polyclonal
• Tested applications: WB
• Reactivity: Human
• Immunogen: N-terminal region of human TSC1
• Dilution range: WB:1:500-1:2000
• Purity: Affinity purification
• Conjugation: Unconjugated
• MW: 130
• UniProt ID: Q92574
• Storage: -20°C
• Buffer/Preservatives: 0.01% NaN3
• Alternative names: anti-TSC1 antibody,anti-Hamartin antibody,anti-Tub
• Note: For research use only
• Expiration Date: 12 months from date of receipt.

Western blot analysis of total cell extracts from human Hela using TSC1 antibody