trans-ACPD

SKU: orb1304158

Description

trans-ACPD is a racemic mixture functioning as a selective group I/II metabotropic glutamate receptor (mGluR) agonist. It is widely used in neuroscience research to study mGluR-mediated signaling, synaptic plasticity, and neuronal excitability in both in vitro and in vivo experimental models.

Research Area

Neuroscience

Key Properties

• CAS Number: 67684-64-4
• MW: 173.17
• Purity: 99.53% (May vary between batches)
• Formula: C₇H₁₁NO₄
• SMILES: NC1(CCC(C1)C(O)=O)C(O)=O
• Target: GluR
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (11.55 mM);1eq. NaOH:50 mM;H2O:5 mM

Bioactivity

• Target IC50:
  mGluR5:23μM(EC50)|mGluR4:800 μM(EC50)|mGluR1:15μM(EC50)|mGluR2:2μM(EC50)
• In Vivo:
  Intrathecal administration of NMDA, kainate, and trans-ACPD, along with the pro-inflammatory cytokines TNF-α or IL-1β, markedly increases biting behavior in mice, a paradigm shift from the control group receiving saline. Pre-systemic intervention with GM at a dosage of 100 mg/kg intraperitoneally notably decreases biting behavior in comparison to saline treatment (10 mL/kg, i.p.), with statistical significance (p<0.001). The efficacy of GM is particularly pronounced against pro-inflammatory cytokines and NMDA, exhibiting inhibition rates of TNF-α (92±7%), IL-1β (91±5%), NMDA (69±1%), and trans-ACPD (71±12%). Conversely, kainate-induced biting responses remain unaffected by GM at the same concentration.
• In Vitro:
  Excitatory amino acid (EAA) analogues activate receptors linked to increased hydrolysis of phosphoinositides (PIs). In these studies, hippocampal slices from neonatal rats (6-11 days old) characterize the effects of EAA analogues on these receptors. The EC50 value of trans-ACPD is 51 μM, and DL-2-Amino-3-phosphonopropionate (DL-AP3) serves as an equally potent inhibitor of PI hydrolysis induced by ibotenate, quisqualate, and trans-ACPD, with IC50 values ranging from 480 to 850 μM .

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

1-amino-1,3-dicarboxycyclopentane, (±)-trans-ACPD, inhibit, Metabotropic glutamate receptors, mGluR5, mGluR, Inhibitor, Trans-ACP, transACPD, trans-ACPD, trans ACPD, Trans-(±)-ACP

Compound Identifiers

PubChem CID

1310