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TPM4 Protein, Human, Recombinant (His)
Catalog Number: orb1956113
| Catalog Number | orb1956113 |
|---|---|
| Category | Proteins |
| Description | TPM4, also known as tropomyosin 4, is a member of the tropomyosin family. Members of this family are actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. TPM4 is expressed in cardiac tissue and platelets. It is highly expressed in the platelets of hypertensive patients. TPM4 plays a central role, in association with the troponin complex, in the calcium-dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells, it is implicated in stabilizing cytoskeleton actin filaments. |
| Tag | N-His |
| Purity | 98.00% |
| MW | 30.8 kDa (predicted); 35-40 kDa (reducing condition, due to glycosylation) |
| UniProt ID | P67936 |
| Expression System | HEK293 Cells |
| Biological Origin | Human |
| Biological Activity | TPM4, also known as tropomyosin 4, is a member of the tropomyosin family. Members of this family are actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. TPM4 is expressed in cardiac tissue and platelets. It is highly expressed in the platelets of hypertensive patients. TPM4 plays a central role, in association with the troponin complex, in the calcium-dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells, it is implicated in stabilizing cytoskeleton actin filaments. |
| Expression Region | A DNA sequence encoding the human TPM4 (P67936) (Ala2-Ile248) was expressed with an N-terminal polyhistidine tag. Predicted N terminal: His |
| Storage | -20°C |
| Note | For research use only |
| Application notes | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
| Expiration Date | 6 months from date of receipt. |
