TOFA

SKU: orb1224713

Description

TOFA (RMI14514, MDL14514) is an indirect, allosteric inhibitor of Acetyl-CoA carboxylase-α (ACCA) and fatty acid synthesis; converted to TOFyl-CoA, exerts an allosteric inhibition on ACCA; lowers blood lipids and inhibits fatty acid synthesis with minimal effects on liver weight and liver fat content; also induces human cancer cell apoptosis through disturbing their fatty acid synthesis.

Key Properties

• CAS Number: 54857-86-2
• MW: 324.45498
• Purity: >98% (HPLC)
• Formula: C₁₉H₃₂O₄
• SMILES: CCCCCCCCCCCCCCOC1=CC=C(O1)C(=O)O
• Target: ACC
• Solubility: DMSO: ≥ 34 mg/mL

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

RMI14514 | MDL14514

Quick Database Links

Gene Symbol

ACC