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TIMP-2 Protein, Human, Recombinant (His)
Catalog Number: orb1962117
| Catalog Number | orb1962117 |
|---|---|
| Category | Proteins |
| Description | Tissue inhibitors of metalloproteinases or TIMPs are a family of proteins that regulate the activation and proteolytic activity of the zinc enzymes known as matrix metalloproteinases (MMPs). There are four members of the family, TIMP-1, TIMP-2, TIMP-3, and TIMP-4. Tissue Inhibitor of Metalloproteinases 2 (TIMP-2) is a non N-glycosylated protein with a molecular mass of 22 kDa. It produced by a wide range of cell types, which inhibits MMPs non-covalently by the formation of binary complexes and irreversibly inactivates them by binding to their catalytic zinc cofactor. TIMP-2 also has erythroid‑potentiating and cell growth promoting activities. |
| Tag | C-6xHis |
| Purity | 98.00% |
| MW | 26 KDa (reducing condition) |
| UniProt ID | P16035 |
| Protein Sequence | Cys27-Pro220 |
| Expression System | HEK293 Cells |
| Biological Origin | Human |
| Biological Activity | Tissue inhibitors of metalloproteinases or TIMPs are a family of proteins that regulate the activation and proteolytic activity of the zinc enzymes known as matrix metalloproteinases (MMPs). There are four members of the family, TIMP-1, TIMP-2, TIMP-3, and TIMP-4. Tissue Inhibitor of Metalloproteinases 2 (TIMP-2) is a non N-glycosylated protein with a molecular mass of 22 kDa. It produced by a wide range of cell types, which inhibits MMPs non-covalently by the formation of binary complexes and irreversibly inactivates them by binding to their catalytic zinc cofactor. TIMP-2 also has erythroid‑potentiating and cell growth promoting activities. |
| Expression Region | Cys27-Pro220 |
| Storage | -20°C |
| Note | For research use only |
| Application notes | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Expiration Date | 6 months from date of receipt. |
- Item 1 of 1
Recombinant human TIMP-2 protein, His [orb1516783]
> 95% as determined by SDS-PAGE
23 kDa
500 μg, 100 μg - Item 1 of 1
Human TIMP2 (His) Protein [orb428858]
Greater than 85% as determined by SDS-PAGE.
E.coli
5 μg, 1 mg, 20 μgRecombinant Human TIMP-2 Protein, His Tag [orb1550369]
> 95% by Tris-Bis PAGE, > 95% by SEC-HPLC
Recombinant Human TIMP-2 Protein is produced by Expi293 expression system. The target protein is expressed with sequence (Cys27-Pro220) of Human TIMP-2 fused with a His Tag at the C-terminal.
100 μgRecombinant Human TIMP-2 Protein, His Tag [orb1551211]
> 95% by SDS-PAGE.
Recombinant Human TIMP-2 Protein is produced by Mammalian expression system. The target protein is expressed with sequence (Cys27-Pro220) of human TIMP-2 (Accession #P16035) fused with a 6xHis Tag at the C- terminus.
50 μg
