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Product Overview
Product Name TG antibody
Catalog Number orb534910
Species/HostMouse
ReactivityHuman
ConjugationUnconjugated
Tested applicationsIHC-P
Immunogen Human thyroid follicular cells
Target Thyroglobulin is a 660kDa dimeric pre-protein with multiple glycosylation sites. It is produced by and processed within the thyroid gland to produce the hormone thyroxine and triiodothyronine. Prior to forming dimers, thyroglobulin monomers undergo conformational maturation in the endoplasmic reticulation. The vast majority of follicular carcinomas of the thyroid will give positive immunoreactivity for anti-thyroglobulin even though sometimes only focally. Poorly differentiated carcinomas of the thyroid are frequently anti-thyroglobulin negative. Adenocarcinomas of other-than-thyroid origin do not react with this antibody. This antibody is useful in identification of thyroid carcinoma of the papillary and follicular types. Presence of thyroglobulin in metastatic lesions establishes the thyroid origin of tumor. Anti-thyroglobulin, combined with anti-calcitonin, can identify medullary carcinomas of the thyroid. Furthermore, anti-thyroglobulin, combined with anti-TTF1, can be a reliable marker to differentiate between primary thyroid and lung neoplasms.
Product Properties
Form/Appearance 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Storage Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months.
Note For research use only.
Isotype IgG1
ClonalityMonoclonal
Purity Purified Ab with BSA and Azide at 200ug/ml
MW 660 kDa
Clone ID rTGB24
Uniprot ID P01266
Entrez 7038
Product Description

Mouse monoclonal antibody to TG

Application Notes
Dilution Range IHC-P: 0.5-1.0 μg/ml for 30 min at RT
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