TET2 antibody

• Catalog Number: orb66693
• Category: Antibodies
• Description: Mouse monoclonal to TET2.TET2 is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). 5-hydroxymethylcytosine may influence chromatin structure andrecruit specific factors or may constitute an intermediate component in cytosine demethylation.TET2 plays an important role in myelopoiesis, and defects in TET2 gene have been associated withseveral myeloproliferative disorders.
• Species/Host: Mouse
• Clonality: Monoclonal
• Tested applications: IP, WB
• Reactivity: Human, Mouse
• Immunogen: multiple regions of human TET2
• Dilution range: WB:1:1000-1:5000,IP:1:50-1:100
• Purity: Ascites
• Conjugation: Unconjugated
• MW: 224
• UniProt ID: Q6N021
• Storage: -20°C
• Buffer/Preservatives: 0.01% NaN3
• Alternative names: anti-TET2 antibody,anti-Methylcytosine dioxygenase
• Note: For research use only
• Expiration Date: 12 months from date of receipt.

Western blot of total cell extracts from a. human Jurkat, b. mouse thymus, using monoclonal anti-TET2 (orb66693) at RT for 2 h.

IP-Western. Total extracts from mouse thymus were immunoprecipitated with a. anti-TET1 (orb66692), b. anti-TET2 (orb66693), c. anti-TET3 (orb66694); followed by WB with rabbit polyclonal anti-TET2 (orb67234) at RT for 2 h.