TET2 antibody

• Catalog Number: orb131790
• Category: Antibodies
• Description: Rabbit polyclonal to TET2. TET2 is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). 5-hydroxymethylcytosine may influence chromatin structure and recruit specific factors or may constitute an intermediate component in cytosine demethylation. TET2 plays an important role in myelopoiesis, and defects in TET2 gene have been associated with several myeloproliferative disorders.
• Species/Host: Rabbit
• Clonality: Polyclonal
• Tested applications: ChIP, IF, IP, WB
• Reactivity: Mouse
• Immunogen: N-terminal region of mouse TET2
• Concentration: 100 μg/ml BSA
• Dilution range: WB:1:1000-1:3000
• Purity: Affinity purification
• Conjugation: Unconjugated
• MW: 224
• UniProt ID: Q4JK59
• Storage: -20°C
• Buffer/Preservatives: 0.01% NaN3
• Alternative names: anti Methylcytosine dioxygenase TET2 antibody, ant
• Note: For research use only
• Application notes: WB: The apparent protein size on WB may be different from the calculated M.W. due to modifications.; ; Experiment Notes: Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the N-terminal region of mouse TET2.
• Expiration Date: 12 months from date of receipt.

References

da Silva, Rodrigo A. et al. Laminar shear stress-provoked cytoskeletal changes are mediated by epigenetic reprogramming of TIMP1 in human primary smooth muscle cells J Cell Physiol, 234, 6382-6396 (2019)

PubMed: 30238981