Teriflunomide (A-771726)

• Catalog Number: orb146201
• Category: Small Molecules
• Description: Teriflunomide: Teriflunomide, aslo know as A77 1726 (trade name Aubagio, marketed by Sanofi) is the active metabolite of leflunomide.
• CAS Number: [163451-81-8]
• MW: 270.21
• SMILES: C(NC1=CC=C(C(F)(F)F)C=C1)(=O)/C(/C#N)=C(\O)/C
• Formula: C₁₂H₉F₃N₂O₂
• Hazard Information: Non-Toxic
• Note: For research use only
• Expiration Date: 12 months from date of receipt.

References

Groh, Janos et al. Immune modulation attenuates infantile neuronal ceroid lipofuscinosis in mice before and after disease onset Brain Commun, 3, (2021)

PubMed: 33977263

Applications

In vivo

Reactivity

Mouse

Hörner, Michaela et al. CNS-associated T-lymphocytes in a mouse model of Hereditary Spastic Paraplegia type 11 (SPG11) are therapeutic targets for established immunomodulators Exp Neurol, 355, 114119 (2022)

PubMed: 35605667

Applications

In vivo

Reactivity

Mouse

Groh, Janos et al. Fingolimod and Teriflunomide Attenuate Neurodegeneration in Mouse Models of Neuronal Ceroid Lipofuscinosis Mol Ther, 25, 1889-1899 (2017)

PubMed: 28506594

Applications

In vivo

Reactivity

Mouse

Chemical structure of Teriflunomide(A-771726).