Tenoxicam

SKU: orb1224529

Description

Tenoxicam, an antiinflammatory agent with analgesic and antipyretic properties, is used to treat osteoarthritis and control acute pain.(In Vitro):Tenoxicam (Ro-12-0068) is a non-steroidal anti-inflammatory drug (NSAID).(In Vivo):Tenoxicam (Ro-12-0068) was administered intraperitoneally immediately after BCAO. Histological analyses show that ischemia produced significant striatal as well as hippocampal lesions which were reversed by the Tenoxicam (Ro-12-0068) treatment. Tenoxicam (Ro-12-0068) also significantly reduced, to control levels, the increased myeloperoxidase activity in hippocampus homogenates observed after ischemia.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 59804-37-4
• MW: 337.37
• Purity: >98% (HPLC)
• Formula: C₁₃H₁₁N₃O₄S₂
• SMILES: O=C(C1=C(O)C2=C(C=CS2)S(N1C)(=O)=O)NC3=NC=CC=C3
• Target: COX
• Solubility: DMSO: 68 mg/mL (201.55 mM)

Bioactivity

• In Vivo:
  Tenoxicam (Ro-12-0068) was administered intraperitoneally immediately after BCAO. Histological analyses show that ischemia produced significant striatal as well as hippocampal lesions which were reversed by the Tenoxicam (Ro-12-0068) treatment. Tenoxicam (Ro-12-0068) also significantly reduced, to control levels, the increased myeloperoxidase activity in hippocampus homogenates observed after ischemia.
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• In Vitro:
  Tenoxicam (Ro-12-0068) is a non-steroidal anti-inflammatory drug (NSAID).

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Ro 12-0068

Quick Database Links

Gene Symbol

COX