Tenovin-6

SKU: orb1307384

Description

Tenovin-6

Research Area

Cell Biology, Epigenetics & Chromatin, Metabolism Research, Molecular Biology

Key Properties

• CAS Number: 1011557-82-6
• MW: 454.63
• Purity: 98.89%
• Formula: C₂₅H₃₄N₄O₂S
• SMILES: CN(C)CCCCC(=O)Nc1ccc(NC(=S)NC(=O)c2ccc(cc2)C(C)(C)C)cc1
• Target: Sirtuin,MDM-2/p53,Dehydrogenase,Autophagy
• Solubility: Ethanol:< 1 mg/mL (insoluble or slightly soluble);H2O:90 mg/mL (197.96 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.26 mM);DMSO:91 mg/mL (200.16 mM)

Bioactivity

• Target IC50:
  SIRT1:21 μM|SIRT3:67 μM|SIRT2:10 μM
• In Vivo:
  Tenovins are active on mammalian cells at one-digit micromolar concentrations and decrease tumor growth in vivo as single agents. Tenovin-6 (50 mg/kg, i.p.) inhibits the growth of tumor in mice.
• Cell Research:
  The MTS assay is used to evaluate cell viability. UM cells are seeded into each well of 96-well plates (5,000 cells/well) and treated the next day with control or Tenovin-6 in an increasing concentrations from 0 to 20 μM for 68 h, and then MTS is added at 20 μL/well to be read at a wave length of 490 nm, the IC50 is determined by curve fitting of the sigmoidal dose-response curve.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Sirtuin, SIRT3, SIRT2, SIRT1, protein-deacetylating, Tenovin 6, Tenovin6, Tenovin-6, inhibit, Inhibitor, MDM2, MDM-2/p53, Dihydroorotate Dehydrogenase, DHODH, degradation, acetylation, Autophagy

Compound Identifiers

PubChem CID

24772043