Teniposide

SKU: orb1308336

Description

Teniposide (VM-26) is a podophyllotoxin-derived chemotherapeutic agent that acts as a topoisomerase II inhibitor, stabilizing the enzyme-DNA complex to block DNA replication. It is widely used in cancer research, demonstrating activity in both in vitro cytotoxicity assays and in vivo models of leukemia and solid tumors.

Research Area

Molecular Biology

Key Properties

• CAS Number: 29767-20-2
• MW: 656.65
• Purity: 99.45% (May vary between batches)
• Formula: C₃₂H₃₂O₁₃S
• SMILES: O=C1[C@@]2([C@@H](C=3C([C@@H](O[C@@H]4O[C@]5([C@]([C@H](O)[C@H]4O)(O[C@@H](OC5)C6=CC=CS6)[H])[H])[C@]2(CO1)[H])=CC7=C(C3)OCO7)C8=CC(OC)=C(O)C(OC)=C8)[H]
• Target: Topoisomerase
• Solubility: DMSO:125 mg/mL (190.36 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.05 mM)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NSC 122819, inhibit, NSC122819, NSC-122819, Inhibitor, Topoisomerase, Topo II, Teniposide, VM26, VM-26, VM 26

Compound Identifiers

PubChem CID

452548