TCPOBOP

SKU: orb1217669

Description

TCPOBOP is a constitutive androstane receptor agonist that induces robust hepatocyte proliferation and hepatomegaly. TCPOBOP decreases Fas-induced murine liver injury by altering Bcl-2 proteins.

Key Properties

• CAS Number: 76150-91-9
• MW: 402.06
• Purity: >98% (HPLC)
• Formula: C₁₆H₈Cl₄N₂O₂
• SMILES: ClC1=CN=C(OC2=CC=C(OC3=NC=C(Cl)C=C3Cl)C=C2)C(Cl)=C1
• Target: Bcl-2
• Solubility: DMSO:25 mg/mL (62.18 mM; ultrasonic and warming and heat to 50°C)

Bioactivity

• In Vivo:
  TCPOBOP (oral; 3 mg/kg; 1-5 days) remarkable increases Liver weight to body weight in LW/BW ratio at 48 hours. Animal model: METfl/fl: Tam-Cre+/+ mice with a targeted deletion for exon 16 with MET KO. Dosage: 3 mg/kg. Administration: Oral; 1, 2, 5 days. Result: Increased Liver weight to body weight.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Bcl-2