SW033291

SKU: orb1306438

Description

SW033291 is a potent and selective 15-PGDH inhibitor with a Ki of 0.1 nM. It elevates tissue PGE2 levels and is utilized in research on tissue regeneration, hematopoiesis, and inflammation, with demonstrated applications in both in vitro assays and in vivo rodent models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 459147-39-8
• MW: 412.59
• Purity: 99.62% (May vary between batches)
• Formula: C₂₁H₂₀N₂OS₃
• SMILES: CCCCS(=O)c1sc2nc(cc(-c3ccccc3)c2c1N)-c1cccs1
• Target: Dehydrogenase
• Solubility: 10% EtOH+90% Corn Oil:0.5 mg/mL (1.21 mM);DMSO:41.3 mg/mL (100.1 mM);Ethanol:8.3 mg/mL (20.12 mM)

Bioactivity

• Target IC50:
  15-PGDH:0.1 nM(Ki)|15-PGDH:1.5 nM
• In Vivo:
  In mice receiving a bone marrow transplant, SW033291 (10 mg/kg, i.p.) promotes hematopoietic recovery. In mouse models of colon and liver injury, SW033291 (10 mg/kg, i.p.) reduces the levels of colitis-associated inflammatory cytokines, protects mice from colitis, and promotes liver regeneration.
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• In Vitro:
  In Vaco-503 cells, SW033291 (2.5 μM) decreases cellular 15-PGDH enzyme activity by 85%.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

prostaglandin, SW033291, SW-033291, SW 033291, Peripheral, PGE2, marrow, Inhibitor, hematopoietic, neutrophil, inhibit, knockout, bone, 15-Hydroxyprostaglandin dehydrogenase, 15-PGDH

Compound Identifiers

PubChem CID

3337839