STEAP1 Antibody

• Catalog Number: orb2193088
• Category: Antibodies
• Description: STEAP1 Antibody: The six-transmembrane epithelial antigen of prostate 1 (STEAP1) was the first member of a family of metalloreductases identified as cell-surface antigens in prostate tissue. The normal function of STEAP is still uncertain; unlike other members of the STEAP family, STEAP1 does not promote iron or copper reduction or uptake and lacks the FNO-like reductase domain critical for activity. However, its expression is highly increased in multiple cancer cell lines, including prostate, bladder, colon, and ovarian cancers. Supporting this is evidence that STEAP1 peptides can be used to stimulate CD8+ T cells from healthy donors, enabling them to recognize STEAP1-positive human tumor cells, suggesting that STEAP1 may a potential target for cancer immunotherapy. At least three isoforms of STEAP1 are known to exist.
• Species/Host: Rabbit
• Clonality: Polyclonal
• Tested applications: ELISA, IHC-P, WB
• Isotype: IgG
• Immunogen: STEAP1 antibody was raised against a 18 amino acid synthetic peptide from near the carboxy terminus of human STEAP1. The immunogen is located within the last 50 amino acids of STEAP1.
• Form/Appearance: Liquid. STEAP1 Antibody is supplied in PBS containing 0.02% sodium azide.
• Conjugation: Unconjugated
• UniProt ID: Q9UHE8
• NCBI: EAL24166
• Storage: STEAP1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
• Buffer/Preservatives: Liquid. STEAP1 Antibody is supplied in PBS containing 0.02% sodium azide.
• Alternative names: metalloreductase STEAP1;PRSS24;six transmembrane e
• Note: For research use only
• Application notes: Application Info: WB: 1-2 ug/mLIHC: 2.5 ug/mLAntibody validated: Western Blot in human samples and Immunohistochemistry in human samples.
• Expiration Date: 12 months from date of receipt.