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SSTR2 Antibody / Somatostatin Receptor 2
Catalog Number: orb1824943
| Catalog Number | orb1824943 |
|---|---|
| Category | Antibodies |
| Description | SSTRs (for somatostatin receptors) represent a family of G protein-coupled receptors which mediate the diverse biological actions of somatostatin (SST). There are five distinct subtypes of SSTRs that bind two natural ligands, SST-14 and SST-28. SSTR2 gives rise to spliced variants, SSTR2A and 2B. SSTRs share common signaling pathways such as the ability to inhibit adenylyl cyclase via GTP binding proteins. Some of the subtypes are also coupled to tyrosine phosphatase (SSTR1,2), Ca2+ channels (SSTR2), Na+/H+ exchanger (SSTR1), PLA-2 (SSTR4), and MAP kinase (SSTR4). Individual target cells typically express more than one SSTR subtype and often all five isoforms. Subtypes of SSTR can form functional homo- and heterodimers. |
| Species/Host | Mouse |
| Clonality | Monoclonal |
| Clone Number | SSTR2/7532 |
| Tested applications | IHC-P |
| Reactivity | Human |
| Isotype | Mouse IgG2b, lambda |
| Immunogen | A recombinant partial protein sequence (within amino acids 300-500) from the human protein was used as the immunogen for the SSTR2 antibody. |
| Antibody Type | Primary Antibody |
| Dilution range | Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT |
| Conjugation | Unconjugated |
| Formula | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide |
| Hazard Information | This SSTR2 antibody is available for research use only. |
| UniProt ID | P30874 |
| Storage | Aliquot the SSTR2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles. |
| Note | For research use only |
| Expiration Date | 12 months from date of receipt. |
IHC staining of FFPE human pancreas tissue with SSTR2 antibody (clone SSTR2/7532). Inset: PBS used in place of primary Ab (secondary Ab negative control). HIER: boil tissue sections in pH9 10 mM Tris with 1 mM EDTA for 20 min and allow to cool before testing.
IHC staining of FFPE human heart tissue with SSTR2 antibody (clone SSTR2/7532). HIER: boil tissue sections in pH9 10 mM Tris with 1 mM EDTA for 20 min and allow to cool before testing.
SDS-PAGE analysis of purified, BSA-free SSTR2 antibody (clone SSTR2/7532) as confirmation of integrity and purity.
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