(+)-Sparteine

SKU: orb1299445

Description

(+)-Sparteine is a class 1a antiarrhythmic alkaloid that acts as a sodium channel blocker and a competitive antagonist of nicotinic acetylcholine receptors. It is utilized in cardiovascular and neuropharmacology research, serving as a tool in electrophysiological studies both in vitro and in vivo.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 492-08-0
• MW: 234.38
• Purity: 99.98% (May vary between batches)
• Formula: C₁₅H₂₆N₂
• SMILES: [C@]12([C@@]3(N(C[C@@](C1)([C@]4(N(C2)CCCC4)[H])[H])CCCC3)[H])[H]
• Target: AChR
• Solubility: DMSO:5 mg/mL (21.33 mM);H2O:2.86 mg/mL (12.2 mM)

Bioactivity

• In Vitro:
  (+)-Sparteine ​​(Pachycarpine) (2 μM) reduces ACh-induced currents caused by activation of nicotinic ACh receptors (AChRs) in a voltage-independent manner at membrane potentials between -50 mV and +30 mV; the ACh dose-response relationship is altered by 2 μM (+)-Sparteine ​​(Pachycarpine) at -50 mV and -90 mV in a manner typical of a competitive but not competitive antagonist.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Pachycarpine, Nicotinic acetylcholine receptors, nAChR, inhibit, Inhibitor, (+) Sparteine, (+)Sparteine, (+)-Sparteine, AChR, Sparteine

Compound Identifiers

PubChem CID

7014