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SMPDL3A Protein, Human, Recombinant (His)
Catalog Number: orb1956423
| Catalog Number | orb1956423 |
|---|---|
| Category | Small Molecules |
| Description | SMPDL3A Protein, Human, Recombinant (His) |
| Purity | 98.00% |
| MW | Approxiamtely 50.3 kDa |
| Biological Activity | SMPDL3A gene is a novel liver X receptor (LXR) -regulated gene, with an LXR response element within its promoter. The induction of SMPDL3A is LXR-dependent and is restricted to human blood cells with no induction observed in mouse cellular systems. LXR α and LXRβ function as physiological sensors of cholesterol metabolites (oxysterols), regulating key genes involved in cholesterol and lipid metabolism. LXRs have been extensively studied in both human and rodent cell systems, revealing their potential therapeutic value in the contexts of atherosclerosis and inflammatory diseases. The LXR genome landscape has been investigated in murine macrophages but not in human THP-1 cells, which represent one of the frequently used monocyte/macrophage cell systems to study immune responses. |
| Note | For research use only |
| Expiration Date | 12 months from date of receipt. |
Recombinant Human SMPDL3A Protein, His Tag [orb1551628]
≥90% as determined by SDS-PAGE
This protein contains the human SMPDL3A(Leu23-Tyr453) was fused with the C-terminal His Tag and expressed in Mammalian cells.
100 μg, 50 μg
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