SLC26A3-IN-2

• Catalog Number: orb1982595
• Category: Small Molecules
• Description: SLC26A3-IN-2 is an orally available and highly potent inhibitor of the anion-exchange protein SLC26A3 for the study of constipation. dCMP disodium (2'2'') is a potent inhibitor of the anion-exchange protein SLC26A3.
• Purity: 100.00%
• MW: 368.84
• Biological Activity: SLC26A3-IN-2 is an orally active compound that functions as an inhibitor of the anion exchanger protein SLC26A3, displaying an IC50 of 360 nM. This protein is a member of the solute carrier (SLC) family, specifically the SLC26 family, known for its broad anion specificity, including chloride, bicarbonate, sulfate, and oxalate. SLC26A3, also known as DRA, is typically down-regulated in adenoma and plays a crucial role in the intestinal absorption of chloride and oxalate. Moreover, mutations resulting in the loss of SLC26A3 function are linked to chloride-losing diarrhea [1].
• CAS Number: 950348-60-4
• Formula: C₁₉H₁₃ClN₂O₂S
• SMILES: O=C1C=C(N=C2SC=C(C=3C=CC=CC3)N12)COC=4C=CC=CC4Cl
• Storage: -20°C
• Note: For research use only