Sivelestat sodium tetrahydrate

SKU: orb1705435

Description

Sivelestat sodium tetrahydrate

Research Area

Infectious Disease & Virology, Protein Biochemistry

Key Properties

• CAS Number: 201677-61-4
• MW: 528.51
• Purity: 99.68%
• Formula: C₂₀H₂₉N₂NaO₁₁S
• SMILES: O.O.O.O.[NaH].CC(C)(C)C(=O)Oc1ccc(cc1)S(=O)(=O)Nc1ccccc1C(=O)NCC(O)=O
• Target: SARS-CoV,Serine Protease
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (9.46 mM);DMSO:225 mg/mL (425.73 mM)

Bioactivity

• In Vivo:
  Sivelestat (ONO-5046, 0.021-2.1 mg/kg, intratracheally) suppresses lung hemorrhage in hamsters (ID50 = 82 pg/kg) and increases skin capillary permeability in guinea pigs (ID50 = 9.6 mg/kg) via intravenous administration, both induced by human neutrophil elastas. Additionally, Sivelestat (10 mg/kg, tail vein infusion) ameliorates lung injury after hemorrhagic shock in rat , and prevents ischemia-reperfusion injury in the rat bladder (15, 60 mg/kg, ip.
• In Vitro:
  Sivelestat (ONO-5046) is not an inhibitor of trypsin, thrombin, plasmin, plasma kallikrein, pancreas kallikrein, chymotrypsin, or cathepsin G, even at concentration up to 100 μ. however, it effectively inhibits neutrophil elastase across various species, demonstrating IC50 Values of 44 nM (human), 36 nM (rabbit), 19 nM (rat), 37 nM (hamster), and 49 nM (mouse), showcasing its specificity and potential for therapeutic application.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Elaspol, Elaspol sodium, Elaspol sodium tetrahydrate, Elaspol sodium Tetrahydrate, ONO 5046, ONO5046 sodium, ONO-5046 sodium, ONO5046 sodium tetrahydrate, ONO5046 sodium Tetrahydrate, ONO-5046 sodium tetrahydrate, ONO-5046 sodium Tetrahydrate, ONO5046, ONO-5046, Neutrophil elastase (human), Serine Protease, SerineProtease, Sivelestat Sodium, Sivelestat sodium, Sivelestat Sodium Hydrate, Sivelestat sodium Tetrahydrate

Compound Identifiers

PubChem CID

173042247