Sildenafil Citrate

• Catalog Number: orb864230
• Category: Small Molecules
• Description: Sildenafil is a phosphodiesterase 5 and 6 (PDE5, PDE6) inhibitor that is clinically used to treat erectile dysfunction and pulmonary arterial hypertension. Sildenafil exhibits antihypertensive (through vasodilatory action), antioxidative, and anti-inflammatory activities. In mouse models of sickle cell anemia, sildenafil promotes eNOS activation and inhibits NADPH oxidase, decreasing oxidative stress. In other animal models, sildenafil decreases Iba-1, IFN-γ, and IL-1β levels and increases glutathione levels, improving myelin structure. This compound also decreases iNOS, TNF-α, and caspase-3 expression in vivo. Additionally, sildenafil restores phosphorylation of smad1/5 and expression of inhibitor of DNA binding protein 1 in animals, preventing vascular remodeling and the development of pulmonary hypertension and potentiating bone morphogenetic protein signaling.
• CAS Number: 171599-83-0
• Purity: ≥99%
• MW: 666.7
• SMILES: CCCC1=NN(C2=C1NC(=NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)C)OCC)C.C(C(=O)O)C(CC(=O)O)(C(=O)O)O
• Formula: C₂₂H₃₀N₆O₄S C₆H₈O₇
• Hazard Information: Non-Toxic
• Solubility (25°C): Insoluble in water, ethanol. Soluble in DMSO to 23 mg/mL, MeOH
• Storage: Storage Temp: Ambient
• Alternative names: Revatio, VIAGRA, Caverta
• Note: For research use only
• Expiration Date: 12 months from date of receipt.