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SIAIS562055

SKU: orb2695222

Description

SIAIS562055 is a cereblon-based SOS1 PROTAC degrader with a Kd of 95.9 nM. It disrupts KRASG12C/SOS1 and KRASG12D/SOS1 interactions and inhibits the ERK pathway, demonstrating potent anticancer activity in cellular studies. This molecule is a valuable research tool for investigating RAS-driven cancers in vitro.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

Key Properties

MW918.12
FormulaC49H62F3N7O5S
TargetPROTACs,Ras

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information