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SIAIS562055

SKU: orb2695222

Description

SIAIS562055, a potent cereblon-based SOS1PROTAC, exhibits a dissociation constant (Kd) of 95.9 nM. It effectively degrades SOS1 and inhibits the downstream ERK pathway. SIAIS562055 disrupts the interaction between KRASG12C or KRASG12D and SOS1, with IC50 values of 95.7 nM and 134.5 nM, respectively. This compound demonstrates strong anticancer activity.

Images & Validation

Key Properties

MW918.12
FormulaC49H62F3N7O5S
TargetRas,PROTACs

Storage & Handling

Storage-20°C
DisclaimerFor research use only
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Protocol Information

SIAIS562055 (orb2695222)

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