Setipiprant

• Catalog Number: orb1304123
• Category: Small Molecules
• Description: Setipiprant
• Purity: 99.16%
• MW: 402.42
• Biological Activity: Setipiprant (ACT-129968) is an orally available, selective CRTH2 antagonist (IC50: 6.0 nM). CRTH2 is a G protein-coupled receptor for prostaglandin (PGD2). PGD2 is produced by the mast cells and is a key mediator in various inflammatory diseases, including allergy and asthma. Binding of PGD2 to CRTH2, which are expressed on the surface of blood-borne cells, induces chemotaxis of Th2 cells, basophils, and eosinophils, and stimulates cytokine release from these cells.
• CAS Number: [866460-33-5]
• Formula: C₂₄H₁₉FN₂O₃
• SMILES: C(C(O)=O)N1C2=C(C=3C1=CC=C(F)C3)CN(C(=O)C=4C5=C(C=CC4)C=CC=C5)CC2
• Storage: -20°C
• Note: For research use only