Setipiprant

SKU: orb1304123

Description

Setipiprant is a potent and selective CRTH2 antagonist (IC50: 6.0 nM) that blocks the PGD2-mediated chemotaxis and activation of Th2 cells, eosinophils, and basophils. It is widely used in preclinical research to investigate allergic asthma and other inflammatory diseases, with applications in both in vitro cellular assays and in vivo animal models.

Research Area

Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 866460-33-5
• MW: 402.42
• Purity: 99.71% (May vary between batches)
• Formula: C₂₄H₁₉FN₂O₃
• SMILES: C(C(O)=O)N1C2=C(C=3C1=CC=C(F)C3)CN(C(=O)C=4C5=C(C=CC4)C=CC=C5)CC2
• Target: GPCR,Prostaglandin Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.97 mM);DMSO:45 mg/mL (111.82 mM)

Bioactivity

• Target IC50:
  DP1 (human):1290 nM|CRTH2:6.0 nM|EP2:2600 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CRTh2, dog, asthma, cAMP, calcium liberation, ACT 129968, ACT129968, ACT-129968, KYTH 105, KYTH105, KYTH-105, inhibit, oral, Inhibitor, HEK-293, rhinitis, ProstaglandinReceptor, Prostaglandin Receptor, Setipiprant, selective, rat

Compound Identifiers

PubChem CID

49843471