SEMA7A Protein, Human, Recombinant (His)

Catalog Number: orb1960161

Catalog Number	orb1960161
Category	Small Molecules
Description	SEMA7A Protein, Human, Recombinant (His)
Purity	98.00%
MW	The protein has a predicted MW of 69.5 kDa. Due to glycosylation, the protein migrates to 70-75 kDa based on Tris-Bis PAGE result.
Biological Activity	Semaphorin7A (Sema7A) plays an important role in the immunoregulation of the brain.Sema7A is upregulated in the epileptic brain and plays a potential role in the regulation of seizure activity in PTZ-kindled epileptic rats, which may be related to neuroinflammation. Sema7A promotes the inflammatory cytokines TNF-α and IL-6 as well as the growth of mossy fibers through the ERK pathway, suggesting that Sema7A may promote seizures by increasing neuroinflammation and activating pathological neural circuits. Sema7A plays a critical role in epilepsy and could be a potential therapeutic target for this neurological disorder.
Note	For research use only
Expiration Date	12 months from date of receipt.

Conjugation:	Unconjugated
Purity:	The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining.
MW:	The protein has a predicted molecular mass of 69.2 kDa after removal of the signal peptide. The apparent molecular mass of SEMA7A-His is approximately 70-100 kDa due to glycosylation.
Source:	Mammalian

Sizes Available: 100 μg, 50 μg, 10 μg

Purity:	≥90% as determined by SDS-PAGE
Source:	This protein contains the human SEMA7A(Met1-Ala648) was fused with the C-terminal His Tag and expressed in Mammalian cells.