Compound E

SKU: orb1694781

Description

γ-Secretase-IN-1 is a potent inhibitor of γ-secretase, effectively suppressing the cleavage of β-amyloid (40/42) and Notch. It demonstrates partial antiproliferative effects in T-47D cell cultures, making it a useful research tool for studying Alzheimer's disease pathways and Notch-related oncology in vitro.

Research Area

Neuroscience, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 209986-17-4
• MW: 490.5
• Purity: >98%
• Formula: C₂₇H₂₄F₂N₄O₃
• SMILES: C[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2N(C)C1=O
• Target: Protease
• Solubility: Soluble in DMSO (up to 25 mg/ml)

Bioactivity

• Target IC50:
  Notch:0.24 nM|β-Amyloid (1–40):0.24 nM|β-Amyloid (1–42):0.37 nM
• In Vitro:
  At a concentration of 50 μM, compound E reduces the proliferation of T47D and MCF-7 cell lines by less than 50% .

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

γ-Secretase Inhibitor XXI; Cpd E

Compound Identifiers

PubChem CID

11306390