Cart summary

You have no items in your shopping cart.

SARS-CoV-2-IN-14

SARS-CoV-2-IN-14

Catalog Number: orb1689487

DispatchUsually dispatched within 3-5 working days
$ 130.00
Catalog Numberorb1689487
CategorySmall Molecules
DescriptionSARS-CoV-2-IN-14
CAS Number22203-98-1
Purity98%
MW282.12
SMILESOc1ccc(Cl)cc1C(=O)Nc1cccc(Cl)c1
FormulaC13H9Cl2NO2
Biological ActivitySARS-CoV-2-IN-14 is a niclosamide analogue. Niclosamide, a widely-used anthelmintic drug, inhibits SARS-CoV-2 virus entry through TMEM16F inhibition and replication through autophagy induction. SARS-CoV-2-IN-14 shows potent inhibition against SARS-CoV-2 with an IC 50 of 0.39 μM which is comparable efficacy to niclosamide. On the other hand, SARS-CoV-2-IN-14 contains higher stability in human plasma and liver S9 enzymes assay than niclosamide, which can improve bioavailability and half-life when administered orally [1].
Storage-20°C
NoteFor research use only
Expiration Date12 months from date of receipt.