Salidroside

SKU: orb1305121

Description

Salidroside

Research Area

Cell Biology, Neuroscience

Key Properties

• CAS Number: 10338-51-9
• MW: 300.304
• Purity: >98%
• Formula: C₁₄H₂₀O₇
• SMILES: O[C@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)[C@@H]1OCCC2=CC=C(O)C=C2
• Target: Prolyl Endopeptidase (PREP),PTEN,Apoptosis,mTOR
• Solubility: DMSO:55.00 mg/mL (183.15 mM);H2O:55.00 mg/mL (183.15 mM);10% DMSO+40% PEG300+5% Tween-80+45% Saline:5.00 mg/mL (16.65 mM);Ethanol:4.00 mg/mL (13.32 mM)

Bioactivity

• In Vivo:
  METHODS: Salidroside (Rhodioloside) (100 mg, oral, once a day. 5 weeks) was used to treat db/db mice after 10 weeks of HFD, and its effect on db/db mice with prediabetes at 4 weeks was observed; after 5 weeks of treatment , conduct OGTT experiment RESULTS Salidroside could not significantly alleviate the elevated blood glucose in db/db mice within the first 15 days; Salidroside protected db/db mice from severe hyperglycemia after 21 days of treatment; Salidroside-treated db/db mice were less Rats' tolerance to glucose was significantly improved.
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• In Vitro:
  METHODS: Min6 cells were co-treated with salidroside (Rhodioloside) (50 μM, 3 days), glucose or H2O2, and the changes in protein levels in β cells were detected by western blot. RESULTS Salidroside downregulated the expression of NOX2 and inhibited the subsequent activation of JNK and caspase 3, thereby preventing β cell death. METHODS: SH-SY5Y cells were treated with Salidroside (Rhodioloside) (25-100 μM, 24 hours) and then exposed to MPP+ (500 μM, 24 hours). Cell viability was determined by MTT assay, cell apoptosis was analyzed by flow cytometry, and cell morphology was evaluated by Hoechst staining. RESULTS Salidroside concentration-dependently prevented the decrease in cell viability induced by MPP+; Salidroside concentration-dependently significantly reduced the number of MPP+-treated annexin V/PI-stained cells; in Hoechst staining, Salidroside significantly inhibited the MPP+-induced increase in chromatin condensation, hyperfluorescence, and nuclear fragmentation in SH-SY5Y cells. METHODS: siDJ-1 transfected H-SY5Y cells were treated with Salidroside (25-100 μM, 24 hours), and then treated with MPP+ (500 μM, 24 hours). , the mRNA expression of DJ-1, Nrf2, GCLc, SOD1 and SOD2 was determined and statistically analyzed. RESULTS Silencing of DJ-1 significantly inhibited the Salidroside-induced increase in mRNA and protein levels (DJ-1, Nrf2, GCLc, SOD1 and SOD2) in MPP+-treated SH-SY5Y cells; silencing DJ-1 also significantly Significantly inhibited the Salidroside-induced decrease in ROS levels and increase in GSH levels in MPP+-treated cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Apoptosis, Mammalian target of Rapamycin, Inhibitor, inhibit, mTOR, POP, prolyl oligopeptidase, Prolyl Endopeptidase (PREP), Salidroside, Rhodioloside

Compound Identifiers

PubChem CID

4961358